Educational use only. This tool and content are for general information and do not constitute medical advice, diagnosis, or treatment. Peptides and GLP-1 medications should only be used under the supervision of a licensed healthcare provider. Always confirm dosing with your prescriber and the product label. Some peptides discussed are not approved by the FDA for human use.

What retatrutide is

Retatrutide is an investigational once-weekly injectable that targets three metabolic receptors — GLP-1, GIP and glucagon. By hitting all three, it appears to drive appetite reduction and fat loss more strongly than single- or dual-agonist drugs in early studies. It is being developed by Eli Lilly and is not yet approved.

How trial dosing is structured

Clinical trials start low and increase slowly to limit nausea. See the retatrutide dosage chart for the weekly doses studied. To convert any dose to syringe units, use the calculator.

Reported side effects

The most commonly reported effects in trials are gastrointestinal — nausea, diarrhea, vomiting and constipation — usually mild-to-moderate and most likely during dose increases. As with other incretin drugs, slow titration and adequate hydration are used to reduce them. This is general information, not a complete safety profile.

Is retatrutide available?

Not as an approved medicine. It cannot be legally prescribed or sold as a finished drug in the U.S. while Phase 3 is ongoing. The realistic, legal options today are: (1) enrolling in a clinical trial, or (2) talking to a licensed telehealth clinician about an FDA-approved GLP-1 such as semaglutide or tirzepatide.

Important: retatrutide is not FDA-approved

Retatrutide is still in Phase 3 trials and cannot be legally prescribed or sold as a finished drug in the U.S. If you want a clinician-supervised, FDA-approved GLP-1 for weight loss today, a licensed telehealth provider can assess whether semaglutide or tirzepatide is right for you.

See FDA-approved options →Find a retatrutide trial

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Frequently asked questions

Can my doctor prescribe retatrutide?

Not as an approved drug — it isn’t available by prescription while in trials. A clinician can discuss approved alternatives like semaglutide or tirzepatide.

Where can I get retatrutide legally?

The legal routes are a clinical trial or an approved alternative through a licensed provider. Products marketed online as research retatrutide are unregulated and not quality-assured.

How does retatrutide compare to Ozempic?

Retatrutide is a triple agonist; semaglutide (Ozempic/Wegovy) is a single GLP-1 agonist. Early data suggest greater weight loss with retatrutide, but it is far less studied and unapproved. See our comparison.

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Retatrutide dosing guide