Retatrutide is one of the fastest-rising topics in the weight-loss space. U.S. search interest has grown more than 27× in under three years as Phase 3 results approach.
Weekly dose ladder studied in trials
| Phase | Weekly dose | Notes |
|---|---|---|
| Starting | 2 mg | Lowest dose used to begin and reduce GI side effects |
| Escalation | 4 mg | Stepped up gradually as tolerated |
| Escalation | 8 mg | Mid-range studied dose |
| Studied maximum | 12 mg | Highest weekly dose in the Phase 2 obesity arm |
Trials escalate slowly — typically every four weeks — to limit nausea and GI effects. Because retatrutide is not approved, there is no official outpatient dosing schedule; the figures above describe what researchers studied, not what you should take.
Convert a dose to syringe units
To turn any milligram dose into the exact units on your insulin syringe, use the retatrutide dosage calculator — enter your vial size and BAC water and it draws the syringe for you.
Important: retatrutide is not FDA-approved
Retatrutide is still in Phase 3 trials and cannot be legally prescribed or sold as a finished drug in the U.S. If you want a clinician-supervised, FDA-approved GLP-1 for weight loss today, a licensed telehealth provider can assess whether semaglutide or tirzepatide is right for you.
See FDA-approved options →Find a retatrutide trialFrequently asked questions
What is the maximum retatrutide dose?
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Is there an official retatrutide dosage chart?
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